Nuclear staining for Notch4 and Survivin had significant differences between the tumor types with type II patients showing a higher percent of positive cells (Notch4: 20%, (intensity: 2-to-3+) versus 5%, (intensity: 1+); Survivin: 75% (intensity: 3+) versus 51% (intensity:1+) (p = 0.0001). Here, NOTCH4 is linked to neoplasm.