Increased expression of the Ptgs2 gene may contribute to the innate immune pathology of both Dusp1−/− and Zfp36−/− mice27, 38, whilst decreased expression of Ptgs2 may play a role in the resistance of Zfp36aa/aa to experimental endotoxemia and arthritis43, 44. The gene discussed is PTGS2; the disease is serum lipopolysaccharide activity.