Moreover, hypoxia-mediated HIF-1α signaling is involved in the amyloidogenic processing of the amyloid precursor protein, and subsequent downstream events influence the activation of the pro-death gene BNIP3, thus leading to an increased incidence of AD and neurodegeneration after cerebral ischemia and stroke62, 64. The gene discussed is ENSG00000280371; the disease is brain ischemia.