In particular, our data emphasize that the PrxII-dependent regulation of TNKS activity is highly specific and unique in several aspects: (1) PrxII is the first redox enzyme directly bound to TNKS via ARC4/5 domains; (2) PrxII selectively targets TNKS in cytosol; and (3) function of PrxII in CRC is specific to deregulated β-catenin pathway (e.g., APC mutation). Here, TNKS is linked to colorectal carcinoma.