Constantly, the treatment of IL-6 at aconcentration of 20 ng/ml significantly promotes the spheroid formation andmigration of RNA polymerase II subunit 5 (RPB5)-mediating protein (RMP) knocks downHCCLM3 cells but not the control cells [20].Since RMP enhances the IL-6 promoter, we assumed that the knockdown of RMP causes areduction in endogenous IL-6, thus allowing the IL-6 treatment to be effective.Taken together, their results suggested that IL-6 treatment can affect themigration, invasion, or proliferation of HCC cells in which endogenous IL-6expression is lacking or was inhibited. This evidence concerns the gene POLR2E and hepatocellular carcinoma.