Cancer-derived BAP1 mutations in the catalytic site, known for abrogating the process of auto-deubiquitylation and promoting its cytoplasmic retention, demonstrate that the BAP1 auto-deubiquitylation event safeguards tumour suppression, suggesting that, in particular, auto-deubiquitylation of BAP1 is a critical event for regulating its cellular proliferation activity [37]. The gene discussed is BAP1; the disease is cancer.