These results suggested that RERG efficiently inhibited the cell proliferation, migration, invasion and angiogenesis of NPC cells by suppressing the cell migratory and pro-angiogenic molecules (MMP-2, MMP-9, IL8, IL6 and IL1β) via the ERK/NF-κB signaling pathway (Fig. 6c), but not VEGF and TNFα. This evidence concerns the gene IL6 and nasopharyngeal carcinoma.