The Ras/MEK//ERK pathway, one of mitogen-activated protein kinases (MAPKs), function in a variety of cellular regulation leading to cell growth and development, and is hyperactivated in a variety of human cancers [34], such as gastric adenocarcinoma, hepatocarcinoma, colon cancer [35, 36] and NPC [37]. Here, WNK2 is linked to malignant colon neoplasm.