In the TEAM data set, 71.8% of samples carried at least one non-silent mutation, which is not significantly different from the 69.0% observed in the ER+ subset of breast cancer samples in TCGA BRCA, and 69.4% of ER+ samples in Stephen et al. (p value 0.558 from Fisher’s proportional test). This evidence concerns the gene ESR1 and breast carcinoma.