In addition, GPRC6A edited PC-3 cells exhibited reduced ligand stimulated expression of transcripts encoding key enzymes regulating intra-tumor androgen biosynthesis, including 17-beta-hydroxysteroid dehydrogenase 11 (HSD17B11), hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1), and aldo-keto reductase family 1, member C3 (ARK1C3). The gene discussed is HSD17B11; the disease is neoplasm.