We confirmed that GPRC6A message is present in several human prostate cancer cell lines [12], including androgen insensitive PC-3 cells (derived from lumbar metastasis), DU145 cells (derived from CNS metastasis), and 22Rv1 cells (derived from androgen insensitive xenograft), and androgen sensitive LNCap cells (derived from lymph node metastasis) (Fig. 1a). This evidence concerns the gene GPRC6A and Familial prostate cancer.