However, CML increased the mRNA and protein levels of HMG-CoAR, LDLr, SREBP-2 and SCAP in the absence or presence of a high concentration of native LDL, and these could be inbibited by anti-RAGE (Fig. 7a, b and c). Here, SCAP is linked to chronic myelogenous leukemia, BCR-ABL1 positive.