In vitro study showed CML increased HMG-CoAR, LDLr, SREBP-2, and SCAP mRNA and protein expression, and enhanced the localization of SCAP to the Golgi in the absence or presence of native LDL loading, which further supported our in vivo findings. Here, LDLR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.