In spite of FMD abnormalities in the T1DM ≥ 5 subgroup when compared with controls (Table 3), we could not find in our study IMT abnormalities in any of the diabetic subgroups (Table 4), which suggests the inexistence of atherosclerotic structural alterations that usually evolve after the advent of endothelial dysfunction. Here, FLNA is linked to type 1 diabetes mellitus.