study (37), in which RBP-4 levels of obese and overweight groups with metabolic disorders were higher than those of the lean group and had a direct association with the BMI, abdominal circumference, waist-to-hip ratio, systolic blood pressure, fasting insulin, HOMA-IR, total cholesterol, and triglyceride (37,38). This evidence concerns the gene RBP4 and Other metabolic disease.