In 10 of 11 archived CCOT samples, mutations were found exclusively in CTNNB1. Similar CTNNB1 mutations have been reported in various cancers such as colorectal or lung adenocarcinoma, but at relatively low frequencies of less than 5% [13], suggesting that such mutations are not essential to many of those tumors. This evidence concerns the gene CTNNB1 and lung adenocarcinoma.