The association between diabetes mellitus and PD can be explained as a manifestation of systemic inflammation and the corresponding mechanisms of insulin sensitivity and glucose dynamics.[26] The increased severity or chronicity of PD increases the insulin resistance and aggravates glycemic control.[27] Many studies have yielded evidence for a link between diabetes mellitus and essential hypertension via hyperinsulinemia.[28,29] Therefore, the interrelatedness of diabetes mellitus, hypertension, and PD may affect the manifestation of the disease. This evidence concerns the gene INS and Hyperinsulinemia.