CDKN2A and cancer: Differential geminin expression is associated with various cancers, including breast cancer, colorectal carcinomas, and small lung adenocarcinoma.[13–15] Suppression of geminin can inhibit cancer cell proliferation without affecting the normal cells.[16] Using high-density microarrays, Martin et al[17] have identified several genes involved in cell cycle regulation that are differentially expressed in premalignant and malignant cervical disease, including geminin, p16, minichromosome maintenance complex component (MCM) 3, and MCM5.