Differential geminin expression is associated with various cancers, including breast cancer, colorectal carcinomas, and small lung adenocarcinoma.[13–15] Suppression of geminin can inhibit cancer cell proliferation without affecting the normal cells.[16] Using high-density microarrays, Martin et al[17] have identified several genes involved in cell cycle regulation that are differentially expressed in premalignant and malignant cervical disease, including geminin, p16, minichromosome maintenance complex component (MCM) 3, and MCM5. Here, MCM5 is linked to cancer.