An experiment reported that acupuncture can decrease the ovalbumin specific IgE level as well as the Th17 cytokine levels (IL-17A, IL-17F, and IL-22) in the serum of the experimental asthma mice.[25] In a clinical study, patients treated by acupuncture were observed improvement of CD3+ cells and CD4+ cells, and decrease in IL-6 and IL-10.[26] In addition, 1 study has demonstrated that acupuncture could reduce airway resistance in people with asthma.[27]. The gene discussed is IL22; the disease is asthma.