It has been confirmed that a lack of suppressor T cells (including CD8+CD28– T cells) induced by intestinal epithelial cells is relevant to IBD.[29] These data agree with Allez et al's[30] finding that mucosal CD8+CD28– T cells can function in anti-inflammatory roles, inhibiting the superabundant immunological reaction to protect the intestinal mucosa from pathological injuries, and CD8+CD28+ T cells can differentiate into CD8+CD28– T cells to maintain active immune suppression. Here, CD28 is linked to inflammatory bowel disease.