CD274 and cancer: Interestingly, our subgrouping approach, which represents a slightly adjusted version of the TIL/PD-L1 based cancer classification proposed by Teng et al. [13], unmasked a comparatively large subgroup of “non-immunogenic”, CD3ilow / PD-L1low ESCCs (48% of all tumors), which were significantly associated with reduced survival parameters in uni- and multivariate analyses, while certain tendencies, but no distinct differences in patient survival were observed between the other subgroups.