However, in ESCC, data regarding its IM are limited and the prognostic value of PD-L1 expression is still a matter of debate, as some studies associate PD-L1 expression with a rather favorable [21, 22] prognosis, while others postulate a less favorable [23–25] disease course for PD-L1 positive cancers. The gene discussed is CD274; the disease is esophageal squamous cell carcinoma.