CSPG4 and cancer: In the following sections, we will provide a short overview of CSPG4-targeting scFv-fusion proteins which have been preclinically evaluated for efficacy towards various refractory cancer types, in particular in rhabdomyosarcoma (RMS), a soft-tissue sarcoma occurring in young children (in the form of embryonal RMS, eRMS) as well as older children and adults (typically alveolar or pleomorphic RMS, aRMS or pRMS) [46].