TP53 and neoplasm: In our previous studies, we found significant changes in glycosylation including sialylation, fucosylation, branching and content of high mannosylated glycans in breast cancer, indicating the presence of metastasis, spread to the lymph nodes and correlation with tumour circulating cells, tumour characteristics such as TP53 mutation or hormone status and systemic features such as oestradiol levels, BMI and mammographic density (Marino et al., 2012; Saldova et al., 2014).