Interestingly, accompanying a robust increase in AC protein expression in the brain of (Figure 2 and Figure 7—figure supplement 2), we found a modest yet significant increase in CREB phosphorylation in the hippocampus and conspicuous mood disorders, especially despair-like behavior, in TRIP-Br1 knockout mice (Figure 7—figure supplement 4). The gene discussed is CXCL11; the disease is mood disorder.