Different molecular tools such as lipid storage (Aouadi et al., 2014), autophagy (Fitzgibbons and Czech, 2016), or program of lysosomal metabolism (Xu et al., 2013) are used by the ATM to buffer and process excessive amounts of lipids and maintain adipose tissue (AT) homeostasis, in the context of metabolic disease. Here, ATM is linked to metabolic disease.