Although earlier studies demonstrated the influence of CYP2C9 genetic polymorphisms on the metabolism and glycaemic response to SUs, data on the association between CYP2C9 genotypes and SU‐induced hypoglycaemia are limited and inconsistent.10 The results of our study indicate that these discrepancies could be explained, at least in part, by the interaction between CYP2C9 and POR genes. Here, CYP2C9 is linked to Hypoglycemia.