Among the new susceptibility loci identified by Gormley et al. (Gormley et al. 2016) and included in our GRS, two lie in or near genes involved in regulation of vascular tone (MEF2D, DOCK4, and SLC24A3) (Dong et al. 2006; Firulli et al. 1996; Kang et al. 2015), while ARMS2, PHACTR1, TGFBR2, LRP1, and NOTCH4 have been previously associated with vascular disease (Delev et al. 2017; Beaudoin et al. 2015; Guo et al. 2016; Hayashi et al. 2010; Yang et al. 2016), consistently with the suggested role of vascular dysfunction in migraine pathogenesis. This evidence concerns the gene NOTCH4 and migraine disorder.