PPARG and Cerebral ischemia: Additionally, aging studies have identified that the proteolytic properties of PPARγ may contribute to progressive loss of cellular metabolic capacity and may contribute to loss of microvascular integrity [2], explaining the comorbidity between cerebral ischemia and neurodegenerative diseases as well as expanding the urgency and impact of therapies for cerebral ischemic injury, which may set in motion the basis for various neurological risks after injury [34].