Using a rat focal cerebral ischemia model (MCAO) and rat cerebral cortical neuron ischemic injury model (OGD), this study aimed to answer whether the ginsenoside Rg1 could activate PPARγ-mediated anti-inflammatory and antioxidative effects, establishing a mechanistic groundwork for Rg1 in the therapeutic scope of ischemic cerebrovascular disease. The gene discussed is PPARG; the disease is Cerebral ischemia.