HAMP and bacterial infectious disease: However, administration of anti-hepcidin Ab remarkably impaired (p < 0.05, Breslow test) the immunoprotection of fish to bacterial infection stimulated by A. hydrophila DNA, as shown by more than 50% and 20% decreases in survival rate at 2 days after A. hydrophila and V. alginolyticus infections, among which the survival rate in V. alginolyticus-infected group was even lower than that of the control group.