To further narrow down candidate ceRNAs, the 3′UTR of the predicted ceRNAs should also contain the MREs of 5 validated SMAD4-targeting miRNAs derived from CRC, including miR-22413–15, miR-20a-5p16, miR-130a-3p17, miR-301a-3p17 and miR-454-3p17. This evidence concerns the gene SMAD4 and colorectal carcinoma.