No differences were detected in the c-Myc protein and Akt phosphorylation and protein levels between shNT and shSET expressing CIP-m cells, and SET KD moreover did not decrease ERK1/2 phosphorylation and protein levels (Fig. 4C), suggesting that SET does not affect these signaling pathways in CIP-m cells. Here, SET is linked to hereditary sensory and autonomic neuropathy.