On the other hand, DHI did alter several genes known to be associated with BP-regulation and hypertension, including kallikrein, plasma kallikrein B1 (Klkb1), 5-hydroxytryptamine (serotonin) receptor 6 (Htr6) and potassium inwardly-rectifying channel, subfamily J, member 2 (Kcnj2) and their differential expressions were validated by RT-PCR from the same RNA source (Fig. 6F). The gene discussed is KLK4; the disease is Hypertension.