RNF157 and neoplasm: We performed siRNA knockdown of RNF157 in the presence or absence of PI3K and MEK inhibitors to evaluate the role of RNF157 in tumor cell survival and found that, whereas RNF157 knockdown modestly increased cell death compared with siControl, simultaneous treatment with siRNF157 and PI3K/MEK inhibitors led to significantly greater cell death than inhibitor treatment alone (Fig. 1E).