In addition, with regards to the stereological analyzes according to the volume of pulp, epithelium, connective tissue, collagenous and non-collagenous matrix, and blood vessels between control and CP groups, it was presented that the transforming growth factor-β1 29C/T [30] and -509C/T [29], tumor necrosis factor-alpha -308G/A [27, 33], interleukine-6-174G/C [4] gene polymorphisms were associated with level of tissue breakdown and periodontal disease progression. This evidence concerns the gene TNF and periodontal disorder.