Recently, Xiao et al. [21], Rauch et al. [44], Derbala et al. [45], Lampertico et al. [46], Egli et al. [47], Eurich et al. [48] have reported that IL-28B polymorphisms associate with the susceptibility to the hepatitis B or C viruses infections, influenza and lower urinary tract symptoms (LUTS). Here, IFNL3 is linked to hepatitis B virus infection.