MAPT and Cognitive impairment: Our previous studies showed that P021 rescues Aβ and tau pathologies in both behaviorally tested (Morris water maze and novel object discrimination tasks) and untested 3 × Tg-AD mice, and that the mice kept on a vehicle diet have higher Aβ and tau pathology burden than those treated with P021; P021 decreased both pathologies markedly and rescued cognitive deficit in 3 × Tg-AD mice [21, 40].