SYP and Alzheimer disease: The expression of synaptophysin in the CA1 region showed a significant increase in the 3 × Tg-AD-P021 compared to WT mice (Fig. 5d and f; two-tailed Student’s t test, p = 0.0450) and a trend towards an increase in the parietal cortex in 3 × Tg-AD-P021 compared to WT mice (Fig. 5d and f; two-tailed Student’s t test, p = 0.0623).