In the cortex, the level of synaptophysin (Fig. 3a and c; two-tailed Student’s t test, p = 0.0014) was reduced significantly while that of GluR1 showed a trend towards a decrease in 3 × Tg-AD mice (Fig. 3a and c; two-tailed Student’s t test, p = 0.06). Here, SYP is linked to Alzheimer disease.