DLG4 and Alzheimer disease: We found a significant increase in the expression of PSD-95 in 3 × Tg-AD-P021 compared to WT and 3 × Tg-AD-vh mice in the CA1 (Fig. 4a and d; one-way ANOVA, post-hoc t test, p = 0.0038) and CA3 regions (Fig. 4a and d; one-way ANOVA, post-hoc t test, p = 0.0010).