Dedifferentiated liposarcomas (DLPS) harbor histone deacetylase 1 (HDAC1) mutations in 8.3% of cases [25], and liposarcoma methylomes show alteration in differentiation genes, including CCAAT/Enhancer Binding Protein Alpha (CEBPA) methylation in 24% of cases. Here, HDAC1 is linked to dedifferentiated liposarcoma.