We analysed the association between PARP1 levels and the mutation status of astrocytoma lineage specific genes such as IDH1, ATRX and TP53. We discovered that samples carrying mutated ATRX (p=0.006) and TP53 (p=0.015) were associated with higher PARP1 expression levels (Table 1). The gene discussed is TP53; the disease is astrocytoma (excluding glioblastoma).