The effect exerted by WJPs on transepithelial electrical resistance (TER) and FITC-conjugated dextran permeability in Caco-2 cells stimulated with TNF-α further demonstrated that its protective properties on the colon in colitis was associated with barrier function by the upregulation of AMP-activated kinase (AMPK) activity [63]. The gene discussed is TNF; the disease is colitis.