This function is not dependent on antioxidant activity of Vit C [47] and seems to be of great importance, taking into account that decreased expression of GLUT3 in both STHdhQ cells (striatal neurons derived from knock-in mice expressing mutant huntingtin; cell model of HD) and R6/2 mice (mouse model of HD) as well as impaired GLUT3 localization at the plasma membrane in HD cells were observed [125]. Here, SLC2A3 is linked to Huntington disease.