PDLIM7 and Hodgkins lymphoma: Hodgkin’s lymphoma (EBV-positive or EBV-negative) is a germinal center-derived B-cell disease [22,40], and thus we hypothesized that every experimental cell culture system had to fulfill three criteria in order to mimic the conditions of EBV-associated cHL: (i) EBV-negative in order to avoid a latency III expression pattern, (ii) germinal center-derived B-cell origin, and (iii) inducibility of permanent LMP1 expression without leakage.