Here, we focus on a recently developed experimental system for EBV-associated cHL and the dynamic three-dimensional (3D) LMP1–TRF2 interaction identified in the mononuclear Hodgkin (H) and diagnostic, multinuclear Reed–Sternberg (RS) cells—the malignant tumor cells of classical cHL [22]. Here, PDLIM7 is linked to classic Hodgkin lymphoma.