TERF2 and Epstein-Barr virus infection: This form of genomic instability is also observed after ex vivo EBV infection of human B-lymphocytes, and is associated with dysfunctional telomeres due to partial displacement of TRF2 [35], gain or loss of telomere signals [36], and low levels of TRF1, TRF2, and POT1 [37].