GRHL3 and neoplasm: In keeping with this hypothesis, Grhl3-deleted mice using both K14-Cre and IVL–Cre are expected to develop SCC equally, and this is supported by preliminary data showing that SCCs formed in K14-Cre cKO mice have complete loss of Grhl3 within the tumour, unlike the surrounding oral epidermis that still contains residual Grhl3 expression [55].