More recently, GRHL3 has been identified as a critical tumour-suppressor in head and neck SCC (HNSCC), a heterogeneous cancer associated with poor survival outcomes [55], and where loss of floxed Grhl3 using K14-driven Cre leads to HNSCC development in the oral cavity of these mice [55]. This evidence concerns the gene GRHL3 and head and neck squamous cell carcinoma.