Pten a potent tumour suppressor gene, is a target gene of GRHL3 that catalyses the conversion of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), leading to repression of the phosphoinositide-3-kinase (PI3K) signalling pathway. The gene discussed is GRHL3; the disease is neoplasm.