Since the cellular growth factor FGF-2 is known to be important in skeletal development and metabolism due to its effects in chemotaxis, mitosis, in the formation of chondrocytes and osteoblasts, and in angiogenesis [16,25,26,27,28], in the current study, we speculated that FGF-2 gene polymorphism and its haplotypes may be related to the occurrence of osteoporosis. This evidence concerns the gene FGF2 and osteoporosis.