The current study has shown a clear relationship between FGF-2 gene polymorphism and bone mass, and by investigating SNPs and haplotype of FGF-2 gene and the risk of osteoporosis, FGF-2 gene was shown to be potentially useful genetic marker for predicting osteoporosis risk in senior and middle-aged Zhuang people. Here, FGF2 is linked to osteoporosis.