Analyses of the distributions of five SNPs of the FGF-2 gene and its genotype in Zhuang osteoporosis patients and normal bone mass individuals showed that five SNPs of the FGF-2 gene, namely, rs308379, rsl2644427, rs3789138, rs308442, and rs3747676, reached Hardy-Weinberg equilibrium by χ2-test (p > 0.05). The gene discussed is FGF2; the disease is osteoporosis.