FGF2 and osteoporosis: By analyzing distributions of FGF-2 gene polymorphism and by exploring correlations between five SNPs of FGF-2 gene and the BMD in osteoporosis patients and in senior and middle-aged normal bone mass controls, the current study demonstrated that rs308442 locus of FGF-2 gene is closely correlated to osteoporosis and that the TA may be the risk genotype of osteoporosis.