Since FGF-2 is known to be important in regulating skeletal development and formation of osteoblasts [15], and previously, Hao et al. [16] observed relationships of plasma FGF-2 levels and polymorphism of FGF-2 gene with the obese phenotype of the Chinese Han population, in the current study, we speculated that FGF-2 gene polymorphism and its haplotypes may be related to the occurrence and development of osteoporosis. This evidence concerns the gene FGF2 and osteoporosis.