ERVW-1 and HELLP syndrome: Consistent with its proven role in human placentation, Syncytin-1 abnormal expression has been observed in various pathological conditions affecting placental and maternal-fetal physiology, i.e., Pre-eclampsia (PE); hemolysis elevated liver enzymes and low platelet count (HELLP) syndrome; Trisomy 21; intrauterine growth restriction (IUGR) and endometriosis.