Therefore, we suspect that Zfp217 may have a potential effect on obesity and its role may be under the control of Pparg. Furthermore, bioinformatics analysis and literature review suggest that Zfp217 may affect adipogenesis by combining with Ezh2. Hence, a series of experiments were performed to test this hypothesis. The gene discussed is EZH2; the disease is obesity due to melanocortin 4 receptor deficiency.