RB1 and neoplasm: Kaplan–Meier PFS plots for the 109-patient cohort separated by letrozole (n=78) or fulvestrant (n=31) treatment and Rb/LMWE expression revealed that the patients with Rb+ and LMWE− tumour had the longest PFS time (median >36.5 months overall and with letrozole; 10.7 months with fulvestrant), compared to Rb+/LMWE+ patients (median=13.4 months; 17 months with letrozole and 4.7 months with fulvestrant) and Rb−/LMWE+ patients who had the shortest PFS time (median=4.2 months; 3.5 months with letrozole and 4.2 months with fulvestrant) (Fig. 6d,e).