This is in accordance with the results of our previous study, where it was not possible to show any perturbation of orexigenic and anorexigenic neuropeptides in the ARC in the 2‐hour period running up to scheduled feeding, and that could have been responsible for driving the large meals of HF diet.10 The value of investigating the homeostatic systems in the hypothalamus within the timeframe of the actual scheduled feeding period is underlined by studies using c‐fos to assess neuronal activation in the hypothalamus. This evidence concerns the gene FOS and hydrops fetalis.