Several annexin A2-interacting proteins, e.g. epithelial growth factor receptor (EGFR)17, migration and invasion enhancer 1 (MIEN1)16, galectin-315, and β1 integrin18, have been described to mediate tumor progression through phosphorylation and translocation of annexin A2 to the cell surface. This evidence concerns the gene ANXA2 and neoplasm.