Other interacting members, such as arrestin β2 (ARRB2)39, tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6)40, prohibitin (PHB)3–5, 41, integrin α4 (ITGA4)42, and inversin (INVS)43 have been recently and/or marginally related to cancer cell motility and invasion. Here, ARRB2 is linked to cancer.