Although it is well known that nephrotoxic drugs (nonsteroidal anti-inflammatory drug, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, immunosuppressant, aminoglycoside, vancomycin, acyclovir, or amphotericin) have kidney impairment effect, the use of these drugs was not associated with AKI in the present study. The gene discussed is ACE; the disease is acute kidney injury.