In our study, eight DEGs (TNC, FAP, GPX3, GRP, ADAMTS5, TRAF6, DHCR7 and FDFT1) were found to involve with the process of AMD by promoting the formation of drusen, regulating the process of CNV, REM and signal transduction pathway or against with oxidative stress. This evidence concerns the gene DHCR7 and age-related macular degeneration.