Based on previous studies, TRAF6 and GPX3 were two AMD-related DEGs [13, 14], two DEGs (FAP and GRP) were choroidal neovascularization-related genes [15, 16] and ADAMTS5 was a retinal pigment epithelium-related DEG [17] which may be involved with AMD. The gene discussed is ADAMTS5; the disease is age-related macular degeneration.