CCL2 and amyotrophic lateral sclerosis: In an effort to investigate the role of MCP1 in the innate immune responses observed in ALS pathology, we generated MCP1-CCR2-hSOD1G93A triple transgenic mice by multiple crosses between the MCP1-CCR2 chemokine-receptor bitransgenic mice [33] and hSOD1G93A mice (Fig. 2a) so that in this triple transgenic mice, MCP1 and CCR2 expressing cells are fluorescently labeled in the hSOD1G93A background.