CCL2 and amyotrophic lateral sclerosis: By examining the expression pattern of MCP1, a pivotal chemokine that has been detected in the CSF and serum of ALS patients and suggested to play a central role in neuroinflammation and neurodegeneration [23, 24, 31, 44, 45], we have started to define the specific components of the innate immune response in ALS cortex and spinal cord at a cellular level.