This gene list comprised of a) known EMT genes that included CDH1, ZEB1 and CDH2 b) genes studied in a subset of carcinomas, unknown in prostate cancer: LSR, S100A14 and DPYSL3 and c) novel unknown EMT and cancer genes such as C1orf116. siRNA experiments indicate it to be a potential novel regulator of EMT. The gene discussed is CDH2; the disease is Familial prostate cancer.