PRNP and Creutzfeldt Jacob disease: The cellular prion protein (PrPC) can misfold into disease-provoking conformers (PrP scrapie; PrPSc) that give rise to several neurodegenerative prion diseases, such as Creutzfeldt-Jakob disease (CJD) in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy in cattle [1].