Interestingly, despite the presence of IL-4Rα early during infection, timely interruption of IL-4Rα mediated signaling after 6 days of infection impaired worm clearance in iCre-/+IL-4Rα-/Lox mice similarly to IL-4Rα-/- mice that lacked the receptor from birth (Fig 3J). The gene discussed is IL4R; the disease is infection.